UPDATES ON BIOMARKERS FOR EARLY DIAGNOSIS OF BONE DISEASES
DOI:
https://doi.org/10.51473/rcmos.v1i1.2024.577Keywords:
Biomarkers, Early Diagnosis, Chronic DiseasesAbstract
Introduction: Biomarkers play a crucial role in the early identification of diseases and the assessment of treatment response. This study aims to explore the efficacy of different biomarkers in predicting and monitoring chronic diseases, with a focus on cardiovascular and oncological conditions. Methodology: A systematic review of studies published between 2010 and 2023 was conducted, analyzing the validity and applicability of specific biomarkers such as troponin, BNP (B-type natriuretic peptide), and CA-125. Randomized controlled trials, cohort studies, and meta-analyses were included. The quality of the studies was assessed using the Jadad scale and the Newcastle-Ottawa method. Results: The analyzed biomarkers showed high sensitivity and specificity for early diagnosis and monitoring of diseases. Troponin was particularly effective in detecting myocardial infarction, while BNP performed well in assessing heart failure. CA-125 was useful for monitoring ovarian cancer progression but had limitations in early detection. Discussion: The analysis indicates that biomarkers can provide valuable information for managing chronic diseases, improving diagnosis and treatment follow-up. However, the accuracy of biomarkers may be affected by variables such as comorbidities and individual patient characteristics. Further studies are needed to validate and refine the use of these biomarkers in different clinical contexts. Conclusion: Biomarkers are promising tools for the detection and monitoring of chronic diseases, with the potential to transform clinical practice. The implementation of biomarkers should be accompanied by further studies to ensure their efficacy and accuracy in various clinical scenarios.
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CABRAL, Hebert Wilson Santos; ANDOLPHI, Bruna Ferreira Galone; FERREIRA, Brunna Vila Coutinho; et al. The use of biomarkers in clinical osteoporosis. Revista da Associação Médica Brasileira, v. 62, p. 368–376, 2016. Disponível em: <https://www.scielo.br/j/ramb/a/MpJzrkPwJhfQWnCXbCfktDS/>. Acesso em: 6 ago. 2024.
FERNÁNDEZ-VILLABRILLE, Sara; MARTÍN-CARRO, Beatriz; MARTÍN-VÍRGALA, Julia; et al. Novel Biomarkers of Bone Metabolism. Nutrients, v. 16, n. 5, p. 605, 2024. Disponível em: <https://www.mdpi.com/2072-6643/16/5/605>. Acesso em: 6 ago. 2024.
FILELLA, Xavier; GUAÑABENS, Núria. Clinical use of bone markers: a challenge to variability. Advances in Laboratory Medicine, v. 5, n. 1, p. 7, 2024. Disponível em: <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11019881/>. Acesso em: 6 ago. 2024.
RH, Christenson. Biochemical markers of bone metabolism: an overview. Clinical biochemistry, v. 30, n. 8, 1997. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/9455610/>. Acesso em: 6 ago. 2024.
SEIBEL, Markus J. Clinical application of biochemical markers of bone turnover. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 50, p. 603–620, 2006. Disponível em: <https://www.scielo.br/j/abem/a/x5SvzTHvgSvjbfTygX7fykC/?lang=en>. Acesso em: 6 ago. 2024.
T, Feng; Y, Xie; W, Xie; et al. Characterization of multi-biomarkers for bone health assessment based on photoacoustic physicochemical analysis method. Photoacoustics, v. 25, 2021. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/35004172/>. Acesso em: 6 ago. 2024.
TR, Kuo; CH, Chen. Bone biomarker for the clinical assessment of osteoporosis: recent developments and future perspectives. Biomarker research, v. 5, 2017. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/28529755/>. Acesso em: 6 ago. 2024.
VASIKARAN, Samuel D.; MIURA, Masakazu; PIKNER, Richard; et al. Practical Considerations for the Clinical Application of Bone Turnover Markers in Osteoporosis. Calcified Tissue International, v. 112, n. 2, p. 148–157, 2023.
Bone Markers in Osteoporosis: Bone Turnover Markers, Bone Formation Markers, Bone Resorption Markers. 2024. Disponível em: <https://emedicine.medscape.com/article/128567-overview>. Acesso em: 6 ago. 2024.
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Copyright (c) 2024 Natanael Falquetto de Sá Raposa, Thiago Vinicius Araujo, Ana Clara Kramer Canhim, Rodrigo Mendes Almeida, Marcos Castro Mendes, Luana de Melo Simmer, Nancy Faber Malavoti (Autor/in)
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