USE OF ANTICOAGULANTS IN PATIENTS WITH ATRIAL FIBRILLATION: A SYSTEMATICREVIEW
DOI:
https://doi.org/10.51473/rcmos.v1i1.2024.640Keywords:
Anticoagulants. Atrial fibrillation. Safety. Stroke prevention. WarfarinAbstract
Atrial fibrillation (AF) is one of the most prevalent cardiac arrhythmias, associated with a
high risk of thromboembolic complications such as stroke. The use of anticoagulants is
essential to prevent these events, with warfarin being widely used for many years. However,
new oral anticoagulants (NOACs), such as apixaban and rivaroxaban, have emerged as safer
and more effective alternatives, especially in vulnerable subgroups like patients with chronic
kidney disease and the elderly. This study reviews recent literature on the use of
anticoagulants in AF patients, comparing NOACs with warfarin in terms of efficacy, safety,
and adherence. Nine studies were selected from PubMed and ScienceDirect databases. The
results indicate that NOACs have a better safety profile concerning hemorrhagic events and
are easier to use due to the lack of frequent monitoring requirements. However, warfarin is
still widely used, especially in lower-income countries, due to its more accessible cost. It is
concluded that while NOACs represent a significant advancement in AF management, their
widespread implementation depends on financial accessibility and the individual suitability of
each patient.
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Copyright (c) 2024 Lara Vitória de Paula Oliveira, Cristiano Frattesi Bernardes, Izabela Regina França Ribeiro, Paulo Roberto de Oliveira Santos (Autor/in)
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